Overview of hemostasis
 
Hemostasis is the process through which bleeding is controlled at a site of damaged or disrupted endothelium and is a dynamic interplay between the subendothelium, endothelium, circulating cells, and plasma proteins. Immediately after blood vessel injury, plasma and cellular components are recruited and activated to minimize bleeding and begin tissue repair. The hemostatic process is often divided into 3 phases—the vascular, platelet, and plasma phases; although it is helpful to divide coagulation into these phases for purposes of understanding, in vivo, they are intimately linked and occur in a continuum. The vascular phase is mediated by the release of locally . . . [Full Text of this Article]


Approach to the patient with excessive bleeding
 

Disorders of primary hemostasis
 
Platelet function disorders
Pathophysiology
Etiology
Clinical presentation
Diagnosis
Treatment
Prognosis and outcomes
Gaps in knowledge
von Willebrand disease
Pathophysiology
Etiology
Clinical presentation
Diagnosis
Treatment
Gaps in knowledge

Disorders of secondary hemostasis
 
Hemophilia A and B (FVIII and FIX deficiency)
Pathophysiology
Etiology
Clinical presentation
Diagnosis
Treatment
Prognosis and outcomes
Gaps in knowledge
Rare factor deficiencies
Pathophysiology
Etiology
Clinical presentation
Diagnosis
Treatment
Prognosis and outcomes
Gaps in knowledge

Disorders of fibrinolysis
 
Pathophysiology
Etiology
Clinical presentation
Diagnosis
Treatment
Prognosis and outcomes
Gaps in knowledge