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Chapter 10
Laboratory hematology
General concepts
Laboratory tests are ordered and interpreted within the context of a specific patient as routine screening during a periodic examination, in the setting of an illness for diagnosis or follow-up, or for preoperative assessment. Clinical judgment is applied in both the selection of tests and in their interpretation, and unexpected results should be considered within the framework of the patient and the disease. Some unexpected results may require confirmation, particularly if the integrity of the specimen cannot be ensured (eg, heparin contamination, wrong collection tube or volume of blood, delayed processing). Additional causes of inaccurate laboratory results include sample mislabeling,
Terminology
Specific laboratory tests
Automated blood cell counting Aperture impedance Optical Erythrocyte analysis Reticulocyte counts Nucleated red blood cells Leukocyte analysis Platelet analysis Examination of peripheral blood smears Bone marrow aspirate and biopsy Immunohistochemical stains Preparation of bone marrow samples for ancillary studies Ancillary testing Flow cytometry Normal hematopoiesis Cytogenetics Molecular diagnostics Southern blotting Polymerase chain reaction Miscellaneous laboratory hematology methods Erythrocyte sedimentation rate Screening and diagnosis of hemoglobinopathies Solubility testing for hemoglobin S G6PD testing Hemostasis and thrombosis Screening coagulation testing Preanalytical variables Mixing studies Coagulation factor activity assays Prothrombin time Activated partial thromboplastin time Combined abnormalities of PT and aPTT Thrombin time Fibrinogen assays Reptilase time Global hemostasis tests von Willebrand factor assays Initial testing for vWD Specialized testing to classify vWD Bleeding disorders with normal screening hemostasis tests Platelet function tests Global primary hemostasis screening tests Specialized testing for acquired thrombocytopenia Assays for platelet antibodies Assays for HIT Assays for TTP and vWF cleaving protease (ADAMTS13) Assays for thrombophilia Antithrombin deficiency Protein C deficiency Protein S deficiency Factor V Leiden and prothrombin gene mutation Antiphospholipid syndrome   CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter What's this?
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