The term "myeloid" derives from the Greek myelos, meaning "marrow." Sometimes the term "myeloid" is used to describe hematologic conditions or diseases not involving the lymphoid tissues or lymphocytes. "Myeloid" is also used to describe disorders primarily involving granulocytes (neutrophils, eosinophils, or basophils) and monocytes. Tissue macrophages (histiocytes), Langerhans cells, and interdigitating dendritic cells also arise from monocytic progenitors or precursors. Other important immunoregulatory dendritic cell types and mast cells derive from marrow progenitors that are distinct from myeloid and monocytic progenitors. This chapter covers disorders of granulocytes, monocytes, histiocytes, and dendritic cells. The myelo proliferative disorders (ie, the . . . [Full Text of this Article]


Granulocytes: neutrophils, eosinophils, and basophils
 
Granulopoiesis
Neutrophil release
Neutrophil clearance
Neutrophil extravasation

Monocytes and tissue histiocytes
 

Dendritic cells
 

Neutrophilia
 

Neutropenia
 
Severe congenital neutropenia (Kostmann syndrome)
Cyclic neutropenia
Shwachman-Diamond syndrome
WHIM syndrome
Chédiak-Higashi syndrome
Neonatal alloimmune neutropenia
Primary autoimmune neutropenia
Secondary autoimmune neutropenia
Large granular lymphocyte leukemia
Nonimmune chronic idiopathic neutropenia
Neutropenia due to idiosyncratic drug reactions
Chemotherapy-induced neutropenia

Disorders of neutrophil function
 
Myeloperoxidase deficiency
Leukocyte adhesion deficiency
Hyperimmunoglobulin E syndrome
Neutrophil-specific granule deficiency
Chronic granulomatous disease
Autoinflammatory diseases

Monocytosis
 

Monocytopenia
 

Disorders of histiocytes and DCs
 
Hemophagocytic lymphohistiocytosis
Langerhans cell histiocytosis
Non–Langerhans cell histiocytoses

Lysosomal storage diseases
 
Gaucher disease
Niemann-Pick disease